Neurophysiol and Noga Vardi Ying Xu , Anuradha Dhingra , Marie E . Fina , Chieko Koike , Takahisa Furukawa inactive mGluR 6 deletion renders the TRPM 1 channel in retina
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منابع مشابه
mGluR6 deletion renders the TRPM1 channel in retina inactive.
In darkness, glutamate released from photoreceptors activates the metabotropic glutamate receptor 6 (mGluR6) on retinal ON bipolar cells. This activates the G protein G(o), which then closes transient receptor potential melastatin 1 (TRPM1) channels, leading to cells' hyperpolarization. It has been generally assumed that deleting mGluR6 would render the cascade inactive and the ON bipolar cells...
متن کاملGβ3 is required for normal light ON responses and synaptic maintenance.
Heterotrimeric G-proteins, comprising Gα and Gβγ subunits, couple metabotropic receptors to various downstream effectors and contribute to assembling and trafficking receptor-based signaling complexes. A G-protein β subunit, Gβ(3), plays a critical role in several physiological processes, as a polymorphism in its gene is associated with a risk factor for several disorders. Retinal ON bipolar ce...
متن کاملKir2.4 surface expression and basal current are affected by heterotrimeric G-proteins.
Kir2.4, a strongly rectifying potassium channel that is localized to neurons and is especially abundant in retina, was fished with yeast two-hybrid screen using a constitutively active Gαo1. Here, we wished to determine whether and how Gαo affects this channel. Using transfected HEK 293 cells and retinal tissue, we showed that Kir2.4 interacts with Gαo, and this interaction is stronger with the...
متن کاملProbing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse.
Retinal ON bipolar cells make up about 70% of all bipolar cells. Glutamate hyperpolarizes these cells by binding to the metabotropic glutamate receptor mGluR6, activating the G-protein G(o1), and closing an unidentified cation channel. To facilitate investigation of ON bipolar cells, we here report on the production of a transgenic mouse (Grm6-GFP) in which enhanced green fluorescent protein (E...
متن کاملAutoantibodies in melanoma-associated retinopathy target TRPM1 cation channels of retinal ON bipolar cells.
Melanoma-associated retinopathy (MAR) is characterized by night blindness, photopsias, and a selective reduction of the electroretinogram b-wave. In certain cases, the serum contains autoantibodies that react with ON bipolar cells, but the target of these autoantibodies has not been identified. Here we show that the primary target of autoantibodies produced in MAR patients with reduced b-wave i...
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تاریخ انتشار 2012